What happens in Churg-Strauss Syndrome?

For reasons unknown, eosinophils, ordinarily a minority of the body's defensive white blood cells, become too numerous and attack healthy tissue.

They may cluster and release harmful granules ("Granulomatosis") in pulmonary organs, and in the circulatory system, inflaming and damaging the blood vessels. 

In a few patients, they  infiltrate the digestive system and damage parts of the abdominal organs which must then be surgically removed. The eosinophils may block or damage capillaries feeding nerves of the hands or feet; these dying nerves produce pain and paralysis.  

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